Valsartan: instructions for use. Medication "Valsartan" - analogues and reviews
Features of pharmacological action
As for the characteristics of pharmacologicalthe action of this antihypertensive drug, then, being a specific antagonist of the so-called angiotensin II receptors, effectively blocks AT1receptors and increases plasma concentrationangiotensin II. In this case, the drug "Valsartan" (the instruction for use explains it by its composition) does not inhibit the angiotensin-converting enzyme. Also, it does not have any agonistic activity with respect to AT1receptors. Among other things, the original "Valsartan" does not block the ion channels and receptors of other hormones, which are extremely important for normal regulation of the cardiovascular system. In addition, this drug has no effect on the level of thyroglobulin, uric acid, total cholesterol and glucose in the blood plasma.
Pharmacokinetics of the drug
If we talk about the pharmacokinetics of such aantihypertensive drug as a drug "Valsartan", then, as a rule, it is very quickly absorbed from the digestive tract after ingestion, although the degree of absorption depends on individual differences.
In this case, a pronounced antihypertensive effect,as a rule, begins to be observed after one hundred and twenty minutes after taking a single dose of the drug, and the maximum therapeutic effect is achieved on average within four to six hours. The absolute bioavailability of this drug is just over 22%. In turn, binding to blood proteins (mainly albumins) is 94-98%. Plasma clearance of the drug "Valsartan", the composition of which has a direct effect on this, is about 2 l / h. This antihypertensive agent is excreted mainly with feces (about 70%) and, to a much lesser extent, with urine. The manufacturer also emphasizes that in case of bile duct obstruction or biliary cirrhosis, the AUC of this drug increases on average by a factor of two. With the course of the drug, no changes in pharmacokinetic properties and parameters are observed.
Description of the medicinal product
An antihypertensive drug is produced"Valsartan" (the instruction for use of which is necessarily included in each package) in the form of tablets coated with a film shell, and in the form of a white powder. This substance is practically insoluble in ordinary water and readily soluble in methanol and ethanol. The molecular weight of this drug is about 430-435. As for the composition of this vasodilator, the main acting elements in it contain an angiotensin II receptor blocker and a thiazide diuretic.
Scope of the drug
Take tablets "Valsartan" instructions forapplication, basically, recommends in the composition of so-called complex therapy to people who suffer from a chronic form of heart failure or hypertension.
In addition, this antihypertensive agentIt is indicated to be used to improve the survival of people with acute myocardial infarction (including complicated systolic ventricular dysfunction or left ventricular failure). Patients with heart diseases who take traditional diuretics are also often prescribed a drug "Valsartan". Analogues of this tool can also be used in all of the above cases.
Dosage of the drug
Take this antihypertensive drugdoctors, as a rule, recommend one or two times a day for eighty or forty milligrams, respectively. In the absence of the necessary therapeutic effect, the daily dosage can be increased. However, it is necessary to do this gradually and only on the prescription of the attending physician. The maximum dosage of this drug is three hundred twenty milligrams.
List of contraindications for use
Use this vasodilatorspecialists categorically do not recommend in the case of a person with increased individual sensitivity to any of its components. With the established allergic reaction, it is also worthwhile to refrain from taking Valsartan tablets. The original drug also should not be taken to patients who have not reached the age of eighteen. The latter circumstance is due to the fact that the safety of the use of this antihypertensive drug in such cases is not fully understood.
Application during pregnancy
Prescribe the drug "Valsartan" to women whobear a child, is strictly contraindicated. Data from organized medical research proves a rather high risk of adverse effects of this antihypertensive drug on the fetus. However, in the case of a life-threatening serious illness in which other, safer drugs can not be used, or they are less effective, the use of this vasodilator medication is allowed. Separately, it should be said about the inadmissibility of using this product during the feeding of a newborn baby with breast milk.
Possible adverse reactions
The purpose of such an antihypertensive drug,as "Valsartan", can cause the appearance of quite severe headaches, dizziness, coughing and weakness. In addition, nausea, diarrhea, hyperkalemia, syncope and insomnia are common. Abdominal pain, vertigo, neutropenia, thrombocytopenia, arthralgia, back pain, myalgia, asthenia and edema can similarly be noted as a result of taking Valsartan. Feedback from patients who previously used it also indicate a risk of developing pharyngitis, rhinitis, sinusitis, various viral infections and infections affecting the upper respiratory tract. Among other things, many people have hyperbilirubinemia, decreased hematocrit, hypercreatininaemia, an increase in the urea nitrogen index and a decrease in hemoglobin. In addition, it should always be remembered that the simultaneous use of vasodilator "Valsartan" and medications from the group of potassium-sparing diuretics can provoke the development of hyperkalemia. In the case of an overdose of the drug, such conditions as bradycardia, tachycardia or hypotension may be observed.
In conclusion, it should be said thatit is necessary with extreme caution and only under strict medical supervision to prescribe the administration of this antihypertensive drug to patients with sodium deficiency, a marked violation in the work of the kidneys, bilateral stenosis of the so-called renal arteries or a marked decrease in the volume of circulating blood. This is primarily due to the high risk of developing a patient's arterial hypotension. In addition, it is worth paying special attention to people suffering from biliary cirrhosis or severe impairment of liver function. Patients with renal artery stenosis require constant control over the concentration of urea nitrogen and the serum creatinine content. Also, patients with bile duct obstruction, who take potassium-sparing diuretics, special potassium supplements or potassium preparations, require special attention to themselves. Finally, with extreme caution, it is necessary to use the antihypertensive agent "Valsartan" to people whose work is related to the driving of any vehicles, and those whose profession is directly associated with a high concentration of attention.