"Fenilin": instructions for use, analogues, reviews
What do they say about such a preparation as "Fenilin"? Reviews of doctors and patients will be considered at the very end of the article. Also we will tell you about the purpose for which this remedy is prescribed, how to correctly take it, whether it has side effects, analogs and contraindications.
Composition and form
In what form is the medicine "Fenilin" made? Instruction for use reports that this drug is available in tablets, the active ingredient of which is fenindion. As auxiliary components use milk sugar, starch, citric acid and talc.
What pharmacological features doesmedicine "Fenilin"? Instructions for use say that this drug has a direct effect on blood coagulability. It is an anticoagulant of indirect action.
Taking medication promotes the emergence ofgipoprotrombinemii, which is due to a violation of the formation of prothrombin in the liver. Also, this agent significantly reduces the formation of factors 7, 9 and 10. Moreover, it has a large cumulative effect in comparison with neodicoumarin.
After oral administration of the tablets, the concentration of coagulation factors decreases within 8-10 hours. The maximum effect of the drug is observed after 25-30 hours.
Is it absorbed into the systemic circulationa medicine "Fenilin"? Experts say that this drug is characterized by a full and fairly rapid absorption. Its active ingredient penetrates through the histohematic barriers and accumulates in the tissues.
The drug is metabolized in the liver, and is excreted by the kidneys (in the form of metabolites and unchanged).
Indications for use
What is the purpose of the Fenilin tablets? Experts say that this drug is used for both treatment and prevention. The main indications for admission are thromboses, thrombophlebitis, thromboembolic complications caused by embolic stroke and myocardial infarction, as well as similar disorders.
In addition, this medication is often prescribed to prevent thrombosis after surgery.
Contraindications for use
At what conditions is the patient forbidden to take the drug "Fenilin"? Instructions for use inform you of the following contraindications:
- disorders in the work of the kidneys and liver;
- initial level of prothrombin up to 70%;
- increased vascular permeability;
- hemorrhagic diathesis and other diseases associated with a decrease in blood coagulability;
- ulcerative diseases of the digestive tract;
- malignant neoplasms;
One can not help saying that the drug in question is not recommended for use at the very beginning of pregnancy, for several days after delivery and during menstruation.
The preparation "Fenilin": instructions for use
The medicament in question is used only forreception inside. His therapeutic scheme has certain characteristics, in this connection, the use of this medicine should only be done according to the doctor's prescription.
The initial daily dose of the drug is usuallyis 0,11-0,17 g (4-time reception). The next day the amount of the drug is reduced to 0.08-0.14 g, and then to 0.02-0.05 g. After that, the dosage of tablets depends on the level of prothrombin in the blood.
The maximum amount of the drug at one time should be 0.05 g, and the daily amount - about 0.2 g.
To prevent thromboembolic complications, it is necessary to take 0.03 g of the drug per day, dividing this dose by two times.
Therapy of acute thrombosis requires additionalreception of heparin. This requires strict monitoring by the doctor, as well as mandatory systematic study of the amount of prothrombin in the blood and other factors of its coagulability.
Treatment with the drug "Fenilin", analogues of which we will list below, are phased out gradually.
Does the drug "Fenilin" cause side effects? The way of application and dosage of this medicine should be strictly observed. This is due primarily to the fact that during therapy, the patient may experience various allergic reactions in the form of diarrhea, nausea and hepatitis. Also, according to reviews of doctors and patients, in rare cases, there are headaches, fever, changes in the color of urine and skin, problems with hematopoiesis.
Signs of an overdose
Overdose in patients may worsensymptoms that are related to side effects. As a treatment for such conditions, it is necessary to cancel the drug, as well as immediate intramuscular injection of "Vikasol", administration of routine, or vitamin P, calcium chloride, ascorbic acid, and general symptomatic therapy.
Drug Interactions of Phenylin
What is the purpose of this remedy, we described above. We turn to additional information.
When a given drug is combined with"Heparin", salicylates, "Ci-methidine" and sulfonamides can increase their anticoagulant effect. At the same time, anabolics, "Allopurinol", "Azathioprine", narcotic analgesics, "Amiodarone", tricyclic antidepressants, antibiotics, glucocorticosteroids, androgens, "Diazoxide", "Dizopiramid", "Isoniazid", " Butadion, Metronidazole, Clofib-rat, Alfa-tocopherol, Reserpine, Quinidine, Paracetamol, Disulfiram, Cyclophosphane, and thyroid hormones.
Noticeably weaken the effect of phenindione mayVitamin K, Propranolol, ascorbic acid, alkalizing urine, Rifampicin, antacids, Fenazone, Haloperidol, barbiturates, oral contraceptives, diuretics, Meprothan, Carbamazepine and Kolestyramine.
With special care this drug is prescribedelderly patients, as well as people with pulmonary embolism, hepatic and renal insufficiency, erosive and ulcerative diseases of the digestive tract, in the postpartum period and with pericarditis.
Treatment with "Phenylline" should be carried out underspecial control of the doctor with the obligatory systematic study of blood on the amount of prothrombin and other coagulation factors. Also, general urine tests are performed to identify early hematuria.
At some patients on a background of reception of a preparation color of urine in pink color, and palms - in orange can be observed. This is due to the metabolism of phenyldione.
The drug "Phenylin": analogues and cost
The main analogues of the drug under consideration are such drugs as Warfapex, Marevan, Neodicumarin, and others.
You can buy a medicine "Fenilin" in the amount of 20 tablets for 120-140 rubles.
Reviews about the drug
Is the medicine "Fenilin" effective? The patients' comments about this drug are very diverse. According to their reports, this remedy is one of the most effective drugs that help improve the blood condition.
Thanks to therapy, blood coagulation ratesmany patients come back to normal. It should also be noted that literally a week after starting treatment, the patient's general condition is improving. At the same time, the numbness of the legs disappears, the person stops worrying with convulsions.
As practice shows, in some patientsbackground of the reception of "Fenilin" tablets, bleeding from the nose becomes more frequent. However, according to doctors, such changes are the norm. After the course of therapy, everything is normalized.
In addition to discussing the effectiveness offunds, you can meet and the stories of patients that this drug is often faked. Therefore at its purchase always there is a risk to get a false medication. In order to avoid such an incident, you should buy medicines only in well-tried pharmacies that have good recommendations.